Emulsification strategies for the preparation of nanoemulsions containing sensitive actives 1251 visningar0 ansökningar

The investigation will aim at testing and evaluating different emulsification approaches for the production of nanoemulsions intended for delivery of sensitive active molecules such as carotenoids. Emulsification methods such as microfluidisation as well as different low energy methods including spontaneous emulsification and phase inversion will be tested. Target prototype formulations may include ophthalmic formulations for delivery of lutein or soft drink formulations containing b-carotene. The experimental data gathered will be the basis for an oral presentation on nanoemulsion formulation at the Formula VIII/NanoFormulation 2016 conference (July 4-7, 2016)

Background

Among the many advantages offered by nanoemulsions in pharma, nutraceutical and beverage applications are their long-term colloidal stability, improved dermal and mucosal transport of actives, improved oral bioavailability and greater aesthetic appeal and skin feel.  A common way of preparing nanoemulsions with drops in the nanometer size range is by means of high-energy methods such as high-pressure homogenization and ultrasonic emulsification. Less common are the milder, low-energy methods such as spontaneous emulsification and phase inversion. These methods are mainly dependent on the tuning of the intrinsic physicochemical properties of the emulsion components and the preparation protocol to yield nanosized emulsion droplets. In the context of pharma, nutraceutical and beverage applications production of nanoemulsions using mild processing conditions (involving low temperatures and low shear) might bring advantages when dealing with sensitive drug molecules or actives prone to degradation and oxidation such as e.g. carotenoids. Looking into the possibilities and limitations of different emulsification protocols for nanoemulsion preparation in terms of i) possible benefits during processing of sensitive actives will help broadening the spectrum of possibilities in the emulsification toolbox for formulators of pharma, cosmetic and nutraceutical nanoemulsions.

Project plan

The work to be carried out will involve the following activities:
• Identification of viable low emulsification routes for preparation of the selected prototype    formulation.
• Setting up of a lab-scale set up for emulsion inversion studies (on line follow up of conductivity, and temperature).
• Studies with no active: Comparison of microfludisation vs. different low energy methods (e.g. spontaneous emulsification or phase inversion methods) for nanoemulsion preparation. Investigations of surfactant concentration effects on resulting emulsion drop size.
• Studies with active (at fixed surfactant concentration): Effect of processing on drop size and stability of the active. Integrity of the active will be assessed by the used od appropriate analytical techniques (e.g. HPLC)

Time plan: The project is estimated to start in early January and be finalized before June 31.

Location: Department of Chemistry Materials and Surfaces, Stockholm facilities (KTH campus)

Remuneration: 20 000 SEK

Applications and Contact Persons at SP:
Interested candidates should send their CV and grade certificates to:
Isabel Mira, Tel: +46 10 516 6064, isabel.mira@sp.se
Martin Andersson, Tel: +46 10 516 60 25, martin.andersson@sp.se

 

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